Laboratory of Drug-Toxicology

Coordinator: Eugenia Gallardo (egallardo@fcsaude.ubi.pt)

The Laboratory of Drug-Toxicology develops its activity in the area of ​​clinical analysis and also in the environmental field – water, food, and others of equal health interest and safeguard public health.

Research

  • Dosing of drugs and xenobiotics in biological matrices;
  • Evaluation of impurities and characterization of active principles;
  • Assay of active substances and contaminants in water and food;
  • Evaluation and characterization of plant extracts;
  • Evaluation of enzymatic activity in material of biotechnological origin.

Services

  • Determination of pesticide residues in water and food;
  • Determination of veterinary residues in food;
  • Determination of metals and metalloids in water, food and biological fluids;
  • Determination of resveratrol in wines;
  • Evaluation of impurities and characterization of active principles;
  • Determination of enzymatic activity in material of biotechnological origin;
  • Dosing of medicaments and xenobiotics in biological matrices;
  • Determination of antioxidant activity in plant extracts;
  • Determination of polyphenols in plant extracts;
  • In vitro toxicity studies;
  • Evaluation of pharmacological interactions between drugs and between drugs and plant extracts;
  • Toxicology consulting services.

Equipment

  • High resolution liquid chromatography coupled to triple quadrupole mass spectrometry (LC-MS / MS)
  • Gas chromatography coupled to a Triple Quadrupole mass spectrometer (GC-MS / MS)
  • Chromatography gas coupled to flame ionization (GC / FID)
  • Gas chromatography coupled mass spectrometry (GC-MS)
  • High resolution liquid chromatography coupled to photodiode detector (HPLC / DAD)
  • High resolution liquid chromatography coupled to fluorescence detector (HPLC / FLD)
  • Vacuum dissecting oven
  • UV/VIS spectrophotometry